WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Antigen processing and presentation       ID:04612
C=76; O=15; E=0.24; R=63.52; rawP=2.62e-23; adjP=9.17e-22
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000168394 NA TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 6890 ENSG00000168394
10  ENSG00000204267 NA TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 6891 ENSG00000204267 ENSG00000250264
11  ENSG00000166710 NA B2M beta-2-microglobulin 567 ENSG00000166710
12  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
13  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865
14  ENSG00000019582 NA CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 972 ENSG00000019582
15  ENSG00000179583 NA CIITA class II, major histocompatibility complex, transactivator 4261 ENSG00000179583


Database:KEGG pathway       Name:Allograft rejection       ID:05330
C=37; O=10; E=0.11; R=86.98; rawP=1.93e-17; adjP=3.38e-16
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
10  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Graft-versus-host disease       ID:05332
C=41; O=10; E=0.13; R=78.50; rawP=6.15e-17; adjP=7.18e-16
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
10  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Type I diabetes mellitus       ID:04940
C=43; O=10; E=0.13; R=74.85; rawP=1.05e-16; adjP=9.19e-16
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
10  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Autoimmune thyroid disease       ID:05320
C=52; O=10; E=0.16; R=61.89; rawP=8.43e-16; adjP=5.90e-15
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
10  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Viral myocarditis       ID:05416
C=70; O=10; E=0.22; R=45.98; rawP=2.02e-14; adjP=1.18e-13
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
10  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Asthma       ID:05310
C=30; O=8; E=0.09; R=85.82; rawP=3.88e-14; adjP=1.94e-13
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
6  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
7  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574


Database:KEGG pathway       Name:Phagosome       ID:04145
C=153; O=12; E=0.48; R=25.24; rawP=7.45e-14; adjP=3.26e-13
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
7  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
8  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
9  ENSG00000168394 NA TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 6890 ENSG00000168394
10  ENSG00000204267 NA TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 6891 ENSG00000204267 ENSG00000250264
11  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
12  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Cell adhesion molecules (CAMs)       ID:04514
C=133; O=11; E=0.41; R=26.62; rawP=4.69e-13; adjP=1.82e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000197646 NA PDCD1LG2 programmed cell death 1 ligand 2 80380 ENSG00000197646
6  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
7  ENSG00000204642 NA HLA-F major histocompatibility complex, class I, F 3134 ENSG00000204642
8  ENSG00000204592 NA HLA-E major histocompatibility complex, class I, E 3133 ENSG00000204592
9  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
10  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
11  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865


Database:KEGG pathway       Name:Leishmaniasis       ID:05140
C=72; O=9; E=0.22; R=40.23; rawP=1.48e-12; adjP=5.18e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000204257 NA HLA-DMA major histocompatibility complex, class II, DM alpha 3108 ENSG00000204257
2  ENSG00000196126 NA HLA-DRB1 major histocompatibility complex, class II, DR beta 1 3123 ENSG00000196126
3  ENSG00000231389 NA HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 3113 ENSG00000231389
4  ENSG00000204287 NA HLA-DRA major histocompatibility complex, class II, DR alpha 3122 ENSG00000204287
5  ENSG00000196735 NA HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3117 ENSG00000196735
6  ENSG00000115415 NA STAT1 signal transducer and activator of transcription 1, 91kDa 6772 ENSG00000115415
7  ENSG00000242574 NA HLA-DMB major histocompatibility complex, class II, DM beta 3109 ENSG00000242574
8  ENSG00000204252 NA HLA-DOA major histocompatibility complex, class II, DO alpha 3111 ENSG00000204252
9  ENSG00000223865 NA HLA-DPB1 major histocompatibility complex, class II, DP beta 1 3115 ENSG00000223865




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).